Angiostrongylus cantonensis has been documented for the first time in tissues of rodents from Budongo Forest Reserve in Uganda. Budongo Forest Reserve (BFR) is situated in Western Uganda in the Disricts of Masindi and Hoima. Thirty-three rodents were humanely captured, euthanized and tissues processed for histological examination. Six % (2/33) of rodents belonging to Lophomurus, sikapusi were infected with Angiostrongylus cantonensis. The parasite was found in the rodent lung tissues with lesions characterized by granulomatous pneumonia, periarteritis, and the presence of eosinophils, macrophages, plasma cells and degenerating adults, eggs and larvae.