The ordination of the first two Baganda priests: Bazilio Lumu and Victoro Womeraka Mukasa at Villa Maria (Buddu County) on June 29, 1913 has been hailed in much of Uganda’s Christian historiography as the ‘beginning’ of the indigenization of the Catholic mission in Buganda and Uganda as a whole. In this article, I use a historical and descriptive approach and draw on archival sources, field interviews to argue that the indigenization of the Catholic mission in Buganda began almost as soon as the first Catholic missionaries arrived in the country in 1879. I further argue that the early indigenization achievements of the Catholic mission in Buganda were occasioned by the vision, attitude, and evangelization methods of Charles Cardinal Lavigarie and members of his White Fathers’ Congregation, the zeal of the first Baganda Catholic converts who were ready to evangelize their kinsmen and the religio-political events that unfolded in Buganda between 1884-92. The article illustrates the earliest intersection of Kiganda culture and Roman Catholicism, and how this shaped the unicity of the mission that emerged in Buganda in the first three decades of the Catholic missionary presence.