Proper management of veterinary drugs, chemicals and biologicals is desirable to ensure quality, safety and efficacy in animal patients. However, the legal regime has entrusted pharmacists with this role, leaving the veterinarians with appropriate knowledge, technical expertise and mandate in supervision of veterinary drug out of the management. Furthermore, the policy of liberalization and privatization of veterinary service delivery has thrown the drug market wide open to businesses leading to possibility of wide spread drug abuse. This has led to non-professional personnel, driven primarily by profit, to fill the void in veterinary drug distribution business. Because of the health related dangers posed to the both animals and ultimately, the human end consumers, a study was designed to evaluate the prevailing management status of veterinary drugs in retail shops with regard to personnel capacity, physical facilities and dispensing practices. The cross sectional study was carried out in Soroti Municipality, headquarter to the district with one of the highest livestock populations in eastern Uganda, using questionnaires and direct observations. Results showed that although all the veterinary drug shops surveyed were located in permanent houses, the general hygiene status at the shops was low at only 40% (n=10). Animal husbandry officers, who are diploma holders were found to dominate the drug distribution business while veterinary surgeons employed non-professional staff to man the shops on their behalf. Overall 60% (n=10) of the shop attendants reported some knowledge about the National Drug Policy and Authority Statute, while 80% were able to distinguish between the different of classes of veterinary drugs. All shops were found to be illegally dealing in class B and class C drugs. Most drug shop attendants (60%) dispensed drugs based on case history only without any other diagnosis, while 20% integrated case history and customer desire to choose the drug to dispense. A large proportion of attendants 86% (n=32) stopped at advising their clients on which drug(s) to purchase. All the attendants dispensed drugs based on brand names but did not label them. Only 20% of the shops had water while records were generally kept. In was concluded that management status of veterinary drugs in retail drug shops are still poor. Therefore there was need for increased vigilance by the National Drug Authority, District and Municipal inspectors to minimize the risks associated poor management of veterinary drugs at retail outlets.